Our informal session will explore emerging topics in the ethical, legal and social issues of human experimentation in space, with special attention to remote healthcare delivery using AI and digital twins. We encourage scholars with interdisciplinary interests in astrobiology, bioethics, space medicine, philosophy, and social studies of science to submit abstracts to present on the topic of AI for space. The Astro-ethics affinity group focuses on how unique features of Outer Space compel new bioethical questions related to the extreme environmental contexts, the uncertain social value and impacts of long duration human space missions, and the necessary scientific and financial collaboration across industry, defense government and public sectors for all to benefit from space exploration.